• 华中科技大学365bet体育注册研究生

华中科技大学化学与化工院_黄开勋

2013-03-19 14:28:26中国365bet体育注册研究生教育信息网

  黄开勋,男,1958年生,现任华中科技大学化学与化工系主任、博士生导师,国务院政府特殊津贴获得者。1982年1月武汉大学化学系获学士学位;1987年6月和1995年6月华中理工大学化学系和生物系获硕士和博士学位。1992年8月-1993年8月在丹麦Roskilde大学生命科学与化学学院合作研究;2000年10月-12月在意大利Padova大学生物化学系高级访问学者;2001年12月-2002年6月在英国Surrey大学生物医学与生命科学学院高级访问学者。

  社会兼职:
  教育部科技委化学化工学部委员
  国家食品药品监督管理局保健食品评审专家
  中国化学会理事、湖北省化学化工学会副理事长
  湖北省硒资源开发与利用促进会理事长

  所授课程:
  1.本科生教学:
  《基础化学》、《药物化学导论》、《化学文献》
  2.研究生教学:
  《蛋白质与核酸的化学》(硕士生)、《化学生物学专题》(博士生)、《无机纳米材料化学》(博士生)

  科学研究与开发:
  (1)硒与活性氮(RNS)在血管疾病、糖尿病发生发展中的作用及其机理;
  (2)无机纳米材料的合成与生物安全性研究;
  (3)新药制剂及功能食品的研究与开发。
  目前主持在研项目:
  (1)国家自然科学基金(20671037):硒和活性氮对胰岛素信号传导系统的调控作用及机理;
  (2)博士点基金:RNA 干扰技术对硒蛋白S 与胰岛素抵抗关系的研究
  (3)973项目子课题(2006CB705606A):纳米材料TiO2安全性解决方案的探索;
  (4)新药研制:①降钙素口腔喷雾剂的临床前研究;②用于手足口病治疗中药研制及其作用机理研究

  发表论文:
  在国内外学术期刊发表论文100多篇,其中SCI论文70余篇,作为副主编出版有硒的专着1本,参编专着3本。其中,近5年代表性论文如下:
  1. Pingtang Zhao and Kaixun Huang*. Preparation and Characterization of Netted Sphere-like CdS Nanostructures. Crystal Growth & Design. 2008, 8(2): 717–722 IF4.339
  2. Pingtang Zhao, Jinmin Wang, Guoe Chen, Zhou Xiao, Jing Zhou, Dean Chen, and Kaixun Huang∗. Hydrothermal Synthesis of PbS Hollow Spheres with Single Crystal-Like Electron Diffraction Patterns. Journal of Nanoscience and Nanotechnology. 2008, 8, 1-7 IF2.194
  3. Guoe Cheng, Kui Wu, Pingtang Zhao, Yang Cheng, Xianliang He, Kaixun Huang*. Controlled growth of oxygen-deficient tin oxide nanostructures via a solvothermal approach in mixed solvents and their optical properties. Nanotechnology. 2007,18(35): 355604 IF 3.037
  4. Zhao Pingtang, Huang Tao, Huang Kaixun*. Fabrication of indium sulfide hollow spheres and their conversion to indium oxide hollow spheres consisting of multipore nanoflakes. Journal of Physical Chemistry C. 2007, 111(35): 12890-12897
  5. Pingtang Zhao, Jinmin Wang, Guoe Cheng, and Kaixun Huang*. Fabrication of Symmetric Hierarchical Hollow PbS Microcrystals via a Facile Solvothermal Process. Journal of Physical Chemistry B. 2006, 110, 22400-22406. IF 4.115
  6. Guoe Cheng, Jinmin Wang, Xiangwen Liu, Kaixun Huang*. Self-Assembly Synthesis of Single- Crystalline Tin Oxide Nanostructures by a Poly (acrylic acid) (PAA)-Assisted Solvothermal Process. Journal of Physical Chemistry B. 2006, 110, 16208-16211, IF 4.115
  7. Yili Ge, Hong Peng, Kaixun Huang*. 31P-NMR study on the autophosphorylation of insulin receptor in the plasma membrane. Analytical and Bioanalytical Chemistry. 2006, 385(5): 834–839. (July 2006, DOI: 10.1007/s00216-006-0507-1) IF 2.591
  8. Qingzhi Wu, Kaixun Huang*. Protective effect of ebselen on cytotoxicity induced by cholestane-3 beta, 3 5 alpha, 6 beta-triol in ECV-304 cells. Biochimica et Biophysica Acta- molecular and cell biology of lipids. 2006, 1761: 350–359. IF 3.117
  9. Chen-Xiao Zhang, Kai-Xun Huang*. Mechanism of apoptosis induced by a polysaccharide, from the loach Misgurnus anguillicaudatus (MAP) in human hepatocellular carcinoma cells. Toxicology and Applied Pharmacology. 2006, 210: 236-245. IF 4.722
  10. Rong Tang, Hongmei Liu, Tiebing Wang, Kaixun Huang*. Mechanisms of selenium inhibition of cell apoptosis induced by oxysterols in rat vascular smooth muscle cells. Archives of Biochemistry and Biophysics 2005,441: 16–24 IF 2.969
  11. Wen-xun Guo, Kai-xun Huang*, Rong Tang, Hui-bi Xu. Synthesis, characterization of novel injectable drug carriers and the antitumor efficacy in mice bearing Sarcoma-180 tumor. Journal of Controlled Release 2005,107: 513–522 IF 4.012
  12. Quan Chi, Tielin Wang, Kaixun Huang*. Effect of insulin nitration by peroxynitrite on its biological activity. Biochemical and Biophysical Research Communications. 2005,330: 791–796 IF 2.855
  13. Tang R, Huang KX*. Inhibiting effect of selenium on oxysterols-induced apoptosis of rat vascular smooth muscle cells. Journal of Inorganic Biochemistry. 2004, 98: 1678–1685. IF 2.654
  14. Guo WX, Huang KX*. New polyanhydrides derived from C12,C13,C14,C15 dibasic acid: synthesis and characterization. Polymer. 2004, 45: 5743–5748. IF 2.773
  15. Wu Q, Huang K*, and Xu H. Effects of long-term selenium deficiency on glutathione peroxidase and thioredoxin reductase activities and expressions in rat aorta. Journal of Inorganic Biochemistry, 2003; 94(4): 301-6 IF 2.654

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